AG490
Product Specifications
Product Name Alternative
Tyrphostin AG490; Tyrphostin B42
UNSPSC Description
AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
Target Antigen
Autophagy; EGFR; JAK; STAT
Type
Reference compound
Related Pathways
Autophagy;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AG-490.html
Purity
99.92
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2
Molecular Weight
294.30
References & Citations
[1]Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3(4):459-63|[2]Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162(7):3897-904.|[3]Davoodi-Semiromi A, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012;7(5):e36079.|[4]Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3(5):703-706.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12000/AG490-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12000/AG490-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
133550-30-8
Available Sizes
Curated Selection
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