AG490

AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

Product Specifications

CAS Number

[133550-30-8]

Product Name Alternative

Tyrphostin AG490; Tyrphostin B42

UNSPSC

12352005

Hazard Statement

H301, H400

Target

Autophagy; EGFR; JAK; STAT

Type

Reference compound

Related Pathways

Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AG-490.html

Purity

99.86

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(NCC1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2

Molecular Formula

C17H14N2O3

Molecular Weight

294.30

Precautions

H301, H400

References & Citations

[1]Dowlati A, et al. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy. Mol Cancer Ther. 2004 Apr;3 (4) :459-63|[2]Wang LH, et al. JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation ofIL-2-mediated T cell response. J Immunol. 1999 Apr 1;162 (7) :3897-904.|[3]Davoodi-Semiromi A, et al. The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One. 2012;7 (5) :e36079.|[4]Cheppudira BP, et al. Anti-hyperalgesic effects of AG490, a Janus kinase inhibitor, in a rat model of inflammatory pain. Biomed Rep. 2015 Sep;3 (5) :703-706.