URB447
URB447 is a peripherally restricted CB1 cannabinoid antagonist (IC50: 313 nM and 41 nM for rat CB1 and human CB2 receptor respectively) . URB447 lowers food intake and body-weight gain in mice without entering the brain or antagonizing central CB1-dependent responses. URB447 can be used for research of obesity[1].
Product Specifications
CAS Number
1132922-57-6
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/urb447.html
Purity
99.5
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)N(CC2=CC=C(C=C2)Cl)C(C3=CC=CC=C3)=C1N)C4=CC=CC=C4
Molecular Formula
C25H21ClN2O
Molecular Weight
400.90
References & Citations
[1]LoVerme J, et al. Synthesis and characterization of a peripherally restricted CB1 cannabinoid antagonist, URB447, that reduces feeding and body-weight gain in mice. Bioorg Med Chem Lett. 2009 Feb 1;19 (3) :639-43.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CB1
Available Sizes
Frequently Asked Questions
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