M617

M617 is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats[1][2].

Product Specifications

CAS Number

[860790-38-1]

UNSPSC

12352209

Target

Neuropeptide Y Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/m617.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@H](C(NCC(=O)N2[C@H](C(N[C@H](C(=O)N3[C@H](C(=O)N4[C@H](C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@H](C(=O)N6[C@H](C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)=O)CCC6)CO)=O)=O)=O)CCC4)CCC3)CCC(N)=O)=O)CCC2)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)C)=O)CO)=O)CC(N)=O)=O)CC(C)C)=O)[C@@H](C)O)=O)NC(CN)=O)C=8C=9C(NC8)=CC=CC9

Molecular Formula

C112H161N29O28

Molecular Weight

2361.65

References & Citations

[1]Lundström, L., et al. A Galanin Receptor Subtype 1 Specific Agonist. Int J Pept Res Ther 11, 17–27 (2005) .|[2]Fang P, et al. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Exp Gerontol. 2015;65:85-89.