Tesmilifene-d4
Tesmilifene-d4 is the deuterium labeled Tesmilifene. Tesmilifene is an antihistamine agent and a chemical sensitizer. Tesmilifene targets cytochrome P450, exhibits hormonal effects on DNA synthesis in MCF-7 cells, and stimulates the tumor growth in mouse/rat models. Tesmilifene overcomes multidrug resistance[1].
Product Specifications
UNSPSC
12352005
Target
Cytochrome P450; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCN(CC)CCOC1=C([2H])C=C(C([2H])([2H])C2=CC=CC=C2)C=C1[2H]
Molecular Formula
C19H21D4NO
Molecular Weight
287.43
References & Citations
[1]Brandes LJ. N, N-diethyl-2-[4- (phenylmethyl) phenoxy] ethanamine (DPPE; tesmilifene), a chemopotentiating agent with hormetic effects on DNA synthesis in vitro, may improve survival in patients with metastatic breast cancer. Hum Exp Toxicol. 2008 Feb;27 (2) :143-7.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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