CSRM617 (hydrochloride)
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model[1]
Product Specifications
CAS Number
1353749-74-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Androgen Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/csrm617-hydrochloride.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(CO)N)N/N=C/C1=CC=C(C(O)=C1O)O.[H]Cl
Molecular Formula
C10H14ClN3O5
Molecular Weight
291.69
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Interleukin 10 (IL10) (Immunoregulation Marker) (IL10/2651R), CF405S conjugate, 0.1mg/mL
