BMS-358233
Product Specifications
UNSPSC Description
PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers[1].
Target Antigen
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/bms-358233.html
Smiles
O=C(C1=CC=C2N=C(NC3=NC(NC[C@@H]4OCCC4)=NC(C)=C3)SC2=C1)NC5=C(C)C=CC=C5Cl
Molecular Weight
509.02
References & Citations
[1]Discovery of 2-Amino-heteroaryl-benzothiazole-6-anilides as Potent p56lck Inhibitors
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120625/BMS-358233-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120625/
Clinical Information
No Development Reported
CAS Number
601519-75-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
