Seliforant

Seliforant (SENS-111) is a selective and orally histamine H4 receptor antagonist.

Product Specifications

CAS Number

[1164115-89-2]

Product Name Alternative

SENS-111

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/seliforant.html

Purity

95.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CNC1CN(C2=NC(CC(C)C)=NC(N)=C2)C1

Molecular Formula

C12H21N5

Molecular Weight

235.33

References & Citations

[1]Petremann M, Gueguen C, Delgado Betancourt V, Wersinger E, Dyhrfjeld-Johnsen J. Effect of the novel histamine H4 receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss. Br J Pharmacol. 2020;177 (3) :623-633. |[2]Venail F, Attali P, Wersinger E, Gomeni R, Poli S, Schmerber S. Safety, tolerability, pharmacokinetics and pharmacokinetic-pharmacodynamic modelling of the novel H4 receptor inhibitor SENS-111 using a modified caloric test in healthy subjects. Br J Clin Pharmacol. 2018;84 (12) :2836-2848.