L-703606

L-703606 is a potent, selective antagonist of NK1 receptor. L-703606 can be used for study of gastric acid secretion[1][2].

Product Specifications

CAS Number

[144425-84-3]

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l-703606.html

Smiles

IC(C=CC=C1)=C1CN[C@@H](C2CCN3CC2)[C@@H]3C(C4=CC=CC=C4)C5=CC=CC=C5

Molecular Formula

C27H29IN2

Molecular Weight

508.44

References & Citations

[1]Minowa S, et al. Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brain. Eur J Pharmacol. 2004;486 (3) :317-324.|[2]Francis BE, et al. Radioiodinated L-703,606: a potent, selective antagonist to the human NK1 receptor. Appl Radiat Isot. 1994;45 (1) :97-103.