Tranylcypromine (hemisulfate)

Tranylcypromine (SKF 385) hemisulfate is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hemisulfate is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Tranylcypromine has antidepressant effects[1][2].

Product Specifications

CAS Number

[13492-01-8]

Product Name Alternative

SKF 385 (hemisulfate)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histone Demethylase; Monoamine Oxidase

Type

Reference compound

Related Pathways

Epigenetics; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Tranylcypromine-hemisulfate.html

Purity

99.94

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 12.5 mg/mL (ultrasonic)

Smiles

N[C@H]1[C@H](C2=CC=CC=C2)C1.[0.5H2SO4]

Molecular Formula

C9H12NO2S0.5

Molecular Weight

182.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Caraci F, et al. Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ (1-42) -induced toxicity. Eur J Pharmacol. 2015 Oct 5;764:256-263.|[2]Sun Q, et al. Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis. Reprod Biol Endocrinol. 2016 Apr 9;14:17.|[3]Tsutsumi T, et al. Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity. Invest Ophthalmol Vis Sci. 2016 Nov 1;57 (14) :6461-6473.|[4]Romanczyk TB, et al. The antidepressant tranylcypromine alters cellular proliferation and migration in the adult goldfish brain. Anat Rec (Hoboken) . 2014 Oct;297 (10) :1919-26.