Ipatasertib-NH2
Ipatasertib-NH2 (GDC-0068-NH2; RG7440-NH2) is a ligand for target protein AKT for PROTAC (INY-03-041) . INY-03-041 is composed of Ipatasertib-NH2, a ten-hydrocarbon linker, and a CRBN ligand Lenalidomide for E3 ubiquitin ligase[1].
Product Specifications
CAS Number
[1001382-14-4]
Product Name Alternative
GDC-0068-NH2; RG7440-NH2
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ipatasertib-nh2.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=C([C@H](C)C[C@H]3O)C3=NC=N2)CC1)[C@@H](C4=CC=C(Cl)C=C4)CN
Molecular Formula
C21H26ClN5O2
Molecular Weight
415.92
References & Citations
[1]You I, et al. Discovery of an AKT Degrader with Prolonged Inhibition of Downstream Signaling. Cell Chem Biol. 2020 Jan 16;27 (1) :66-73.e7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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