5-HT7R antagonist 2

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].

Product Specifications

CAS Number

[1448808-50-1]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht7r-antagonist-2.html

Solubility

10 mM in DMSO

Smiles

COC1=C(C2=CC=CC(C3=NCCN3)=C2)C=CC=C1

Molecular Formula

C16H16N2O

Molecular Weight

252.31

References & Citations

[1]Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15 (5) :1026-1041.