5-HT7R antagonist 2
Product Specifications
UNSPSC Description
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].
Pharmacokinetic Analysis ICR Male Mice[1]
药代动力学分析[1]
Plasma
Intravenous Administration
Intraperitoneal Administration
Tmax (h)
0.08
0.25
T1/2 (h)
0.77
1.06
Cmax (ng/mL)
33.07
156.44
AUClast (ng·h/mL)
28.31
143.27
CL (L/h/kg)
41.61
-
Vss (L/kg)
32.43
-
MRT (h)
0.79
0.93
F (%)
50.60
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht7r-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C2=CC=CC(C3=NCCN3)=C2)C=CC=C1
Molecular Weight
252.31
References & Citations
[1]Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15(5):1026-1041.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-163345/5-HT7R-antagonist-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-163345/
Clinical Information
No Development Reported
CAS Number
1448808-50-1
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