RFRP-1 (human) (TFA)
RFRP-1 (human) TFA is a potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively) . Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.
Product Specifications
UNSPSC
12352209
Target
Neuropeptide Y Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rfrp-1-human-tfa.html
Solubility
10 mM in DMSO
Smiles
OC(C(F)(F)F)=O.NC([C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]2N(CCC2)C([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@@H](NC([C@H](CO)NC([C@H](CC3=CN=CN3)NC([C@H]4N(CCC4)C([C@@H](N)CCSC)=O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C67H101N19O14S.xC2HF3O2
Molecular Weight
1428.70 (free base)
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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