BML-280
BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research[1][2].
Product Specifications
CAS Number
1158347-73-9
Product Name Alternative
VU0285655-1
UNSPSC
12352005
Target
Interleukin Related; Phospholipase; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bml-280.html
Purity
99.64
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=CC=CC=C2N=C1)NCCN(CC3)CCC3(N(C4=CC=CC=C4)CN5)C5=O
Molecular Formula
C25H27N5O2
Molecular Weight
429.51
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-8; PLD; TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
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