Veratramine (Standard)
Veratramine (NSC17821; NSC23880) (Standard) is the analytical standard of Veratramine. This product is intended for research and analytical applications. Veratramine (NSC17821; NSC23880) is an orally active inhibitor of the PI3K/Akt/mTOR signaling pathway and a SIGMAR1 modulator. Veratramine induces autophagic apoptosis of tumor cells, arrests the cell cycle at the G0/G1 phase, and inhibits epithelial-mesenchymal transition (EMT) -related proteins to reduce tumor migration. Veratramine reduces spinal cord and sciatic nerve pathological damage in a neuropathy model by inhibiting SIGMAR1 binding to NMDAR and phosphorylation of NMDAR Ser896. Veratramine has anti-tumor proliferation, apoptosis induction, anti-inflammatory and neuroprotective activities, and can be used in the study of cancers such as liver cancer and osteosarcoma, as well as diabetic peripheral neuropathy[1][2][3][4].
Product Specifications
CAS Number
60-70-8
Product Name Alternative
NSC17821 (Standard) ; NSC23880 (Standard)
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; mTOR; PI3K; Reference Standards
Type
Reference Standards
Related Pathways
Apoptosis; Autophagy; Others; PI3K/Akt/mTOR
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/veratramine-standard.html
Purity
99.90
Smiles
O[C@H]1[C@H]([C@H](C2=C(C)C3=C(C=C2)[C@]4([H])CC=C(C[C@@H](O)CC5)[C@@]5(C)[C@@]4([H])C3)C)NC[C@@H](C)C1
Molecular Formula
C27H39NO2
Molecular Weight
409.60
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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