5-HT6 inverse agonist 1
5-HT6 inverse agonist 1 (Compound 33) is an antagonist for 5-HT6 receptor with a Ki of 23 nM and a Kb of 6.62 nM. 5-HT6 inverse agonist 1 inhibits the 5-HT6R mediated Cdk5 and mTOR signaling pathway. 5-HT6 inverse agonist 1 reduces tactile hypersensitivity in spinal nerve ligation (SNL) -induced rat model[1].
Product Specifications
CAS Number
[2727088-38-0]
UNSPSC
12352005
Target
5-HT Receptor; CDK; mTOR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht6-inverse-agonist-1.html
Smiles
O=C(NC1CCNCC1)C2=C(N(C=C2)S(=O)(C3=CC=CC(Cl)=C3)=O)C4=CC=C(C=C4)F.Cl
Molecular Formula
C22H22Cl2FN3O3S
Molecular Weight
498.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MLAG-3; MUC2; MUC3; α-1 microglobulin
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