15-deoxy-Δ12,14-Prostaglandin D2
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2) . 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC50=8 nM) . 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50=320 ng/mL) .
Product Specifications
CAS Number
[85235-11-6]
Product Name Alternative
15-Deoxy-Δ12,14-PGD2
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Endogenous Metabolite; PPAR; Prostaglandin Receptor; Src
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/15-deoxy-12-14-prostaglandin-d2.html
Concentration
2.99 mM * 1 mL in Methyl acetate
Purity
98.0
Smiles
O=C1/C([C@H]([C@H](C1)O)C/C=C\CCCC(O)=O)=C/C=C/CCCCC
Molecular Formula
C20H30O4
Molecular Weight
334.45
Precautions
H225, H319, H336
References & Citations
[1]Bundy, et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J. Med. Chem. 26 (6), 790-799 (1983) .
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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