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MK-8719

MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].

Product Specifications

CAS Number

[1382799-40-7]

UNSPSC

12352005

Target

OGA

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mk-8719.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 6.67 mg/mL

Smiles

O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F

Molecular Formula

C9H14F2N2O3S

Molecular Weight

268.29

References & Citations

[1]Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

Curated Selection

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