MK-8719

MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].

OGA

Reference compound

Neuronal Signaling

Neurological Disease

https://www.medchemexpress.com/mk-8719.html

99.55

DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 6.67 mg/mL

O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F

268.285

[1]Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-130121/MK-8719-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-130121/MK-8719-SDS-MedChemExpress.pdf

Phase 1

1382799-40-7