MK-8719
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1].
Product Specifications
CAS Number
1382799-40-7
UNSPSC
12352005
Target
OGA
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mk-8719.html
Purity
99.55
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 6.67 mg/mL
Smiles
O[C@H]1[C@H](O)[C@@]2([H])N=C(NCC)S[C@@]2([H])O[C@@H]1C(F)F
Molecular Formula
C9H14F2N2O3S
Molecular Weight
268.29
References & Citations
[1]Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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