Dendrotoxin I

<strong>Dendrotoxin I</strong> <strong>Catalog number:</strong> MDP0697 <strong>CAS Number: </strong>374675-21-5 <strong>Sequence: </strong>Pyr-Pro-Leu-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asp-Pro-Gly-Arg-Cys-Tyr-Gln-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Gly-Phe-Thr-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Arg-Lys (Disulfide bonds between Cys7-Cys57, Cys16-Cys40, and Cys32-Cys53) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 7133.2 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Nishio H, Inui T, Nishiuchi Y, De Medeiros CL, Rowan EG, Harvey AL, Katoh E, Yamazaki T, Kimura T, Sakakibara S. Chemical synthesis of dendrotoxin-I: revision of the reported structure J Pept Res. 1998 May;51(5):355-64. 2: Katoh E, Nishio H, Inui T, Nishiuchi Y, Kimura T, Sakakibara S, Yamazaki T. Structural basis for the biological activity of dendrotoxin-I, a potent potassium channel blocker Biopolymers. 2000 Jul;54(1):44-57. 3: Lucchesi K, Moczydlowski E. Subconductance behavior in a maxi Ca2(+)-activated K+ channel induced by dendrotoxin-I Neuron. 1990 Jan;4(1):141-8. 4: Schweitz H, Bidard JN, Maes P, Lazdunski M. Charybdotoxin is a new member of the K+ channel toxin family that includes dendrotoxin I and mast cell degranulating peptide Biochemistry. 1989 Dec 12;28(25):9708-14. 5: Nishio H, Katoh E, Yamazaki T, Inui T, Nishiuchi Y, Kimura T. Structure-activity relationships of calcicludine and dendrotoxin-I, homologous peptides acting on different targets, calcium and potassium channels Biochem Biophys Res Commun. 1999 Aug 27;262(2):319-21. 6: Rehm H, Lazdunski M. Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I Proc Natl Acad Sci U S A. 1988 Jul;85(13):4919-23. 7: Mourre C, Lazdunski M, Jarrard LE. Behaviors and neurodegeneration induced by two blockers of K+ channels, the mast cell degranulating peptide and Dendrotoxin I Brain Res. 1997 Jul 11;762(1-2):223-7. 8: Foray MF, Lancelin JM, Hollecker M, Marion D. Sequence-specific 1H-NMR assignment and secondary structure of black mamba dendrotoxin I, a highly selective blocker of voltage-gated potassium channels Eur J Biochem. 1993 Feb 1;211(3):813-20. 9: Stutzmann JM, Böhme GA, Gandolfo G, Gottesmann C, Lafforgue J, Blanchard JC, Laduron PM, Lazdunski M. Riluzole prevents hyperexcitability produced by the mast cell degranulating peptide and dendrotoxin I in the rat Eur J Pharmacol. 1991 Feb 7;193(2):223-9. <a href="https://pubmed.ncbi.nlm.nih.gov/2550111">10: Bidard JN, Mourre C, Gandolfo G, Schweitz H, Widmann C, Gottesmann C, Lazdunski M. Analogies and differences in the mode of action and properties of binding sites (localization and mutual interactions) of two K+ channel toxins, MCD peptide and dendrotoxin I Brain Res. 1989 Aug 21;495(1):45-57. </a> <br><strong>Products Related to Dendrotoxin I can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>