Theaflavin-3'-gallate

Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC50 of 7.6 μM[1][2][3].

Product Specifications

CAS Number

[28543-07-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Necroptosis; Xanthine Oxidase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/theaflavin-3-gallate-1.html

Concentration

10mM

Purity

98.79

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(O[C@H]1[C@@H](C2=C(C=C([C@@H]3[C@H](O)CC4=C(O)C=C(O)C=C4O3)C=C(O)C5=O)C5=C(O)C(O)=C2)OC6=CC(O)=CC(O)=C6C1)C7=CC(O)=C(O)C(O)=C7

Molecular Formula

C36H28O16

Molecular Weight

716.60

Precautions

H302, H315, H319

References & Citations

[1]Babich H, et al. Theaflavin-3-gallate and theaflavin-3'-gallate, polyphenols in black tea with prooxidant properties. Basic Clin Pharmacol Toxicol. 2008 Jul;103 (1) :66-74.|[2]J K Lin, et al.Inhibition of xanthine oxidase and suppression of intracellular reactive oxygen species in HL-60 cells by theaflavin-3,3'-digallate, (-) -epigallocatechin-3-gallate, and propyl gallate. J Agric Food Chem. 2000 Jul;48 (7) :2736-43.|[3]Xin Zheng, et al. Anti-damage effect of theaflavin-3'-gallate from black tea on UVB-irradiated HaCaT cells by photoprotection and maintaining cell homeostasis. J Photochem Photobiol B. 2021 Nov:224:112304.