Palovarotene

Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.

Product Specifications

CAS Number

[410528-02-8]

Product Name Alternative

R 667; Ro 3300074

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; RAR/RXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Palovarotene.html

Concentration

10mM

Purity

99.49

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=C(/C=C/C2=C(CN3N=CC=C3)C=C4C(C)(C)CCC(C)(C)C4=C2)C=C1

Molecular Formula

C27H30N2O2

Molecular Weight

414.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.|[2]Chakkalakal SA, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1 (R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31 (9) :1666-75.|[3]Lees-Shepard JB, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity. Elife. 2018 Sep 18;7. pii: e40814.