Palovarotene
Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.
Product Specifications
CAS Number
410528-02-8
Product Name Alternative
R 667; Ro 3300074
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Palovarotene.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(/C=C/C2=C(CN3N=CC=C3)C=C4C(C)(C)CCC(C)(C)C4=C2)C=C1
Molecular Formula
C27H30N2O2
Molecular Weight
414.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Pavey GJ, et al. Targeted stimulation of retinoic acid receptor-γ mitigates the formation of heterotopic ossification in an established blast-related traumatic injury model. Bone. 2016 Sep;90:159-67.|[2]Chakkalakal SA, et al. Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1 (R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res. 2016 Sep;31 (9) :1666-75.|[3]Lees-Shepard JB, et al. Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity. Elife. 2018 Sep 18;7. pii: e40814.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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