IMAC2 (hydrochloride)
IMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC50 of 28 nM and a LD50 of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release[1].
Product Specifications
CAS Number
[335166-00-2]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/imac2-hydrochloride.html
Purity
93.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3.Cl.Cl
Molecular Formula
C19H22Br2Cl2FN3
Molecular Weight
542.11
Precautions
H315, H319, H320
References & Citations
[1]Peixoto PM, et al. MAC inhibitors suppress mitochondrial apoptosis. Biochem J. 2009 Oct 12;423 (3) :381-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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