IMAC2 (hydrochloride)

IMAC2 hydrochloride is a potent MAC (mitochondrial apoptosis-induced channel) inhibitor, with an IC50 of 28 nM and a LD50 of 15000 nM. iMAC2 hydrochloride shows anti-apoptotic effect. iMAC2 hydrochloride blocks cytochrome c release[1].

Product Specifications

CAS Number

[335166-00-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/imac2-hydrochloride.html

Purity

93.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3.Cl.Cl

Molecular Formula

C19H22Br2Cl2FN3

Molecular Weight

542.11

Precautions

H315, H319, H320

References & Citations

[1]Peixoto PM, et al. MAC inhibitors suppress mitochondrial apoptosis. Biochem J. 2009 Oct 12;423 (3) :381-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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