Withanolide B

Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3].

Product Specifications

CAS Number

[56973-41-2]

UNSPSC

12352005

Target

ERK; RUNX; Wnt; β-catenin

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/withanolide-b.html

Purity

99.0

Solubility

Acetone : 1 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 3.33 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@@]([C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)C)C)C)([H])[C@H]6[C@@H]([C@]1(CC=CC2=O)O)O6

Molecular Formula

C28H38O5

Molecular Weight

454.60

References & Citations

[1]Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. |[2]Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. |[3]Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9 (8) :e104005.