Human PTHrP- (1-36)

Human PTHrP- (1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP- (1-36) enhances beta cell function and proliferation. Human PTHrP- (1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism[1][3].

Product Specifications

CAS Number

[172867-62-8]

UNSPSC

12352209

Target

PTHR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/human-pthrp-1-36.html

Purity

99.05

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC(C)C)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC7=CNC=N7)C(N[C@@H]([C@H](O)C)C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C191H305N59O52

Molecular Weight

4259.83

References & Citations

[1]Everhart-Caye M, et al. Parathyroid hormone (PTH) -related protein (1-36) is equipotent to PTH (1-34) in humans. J Clin Endocrinol Metab. 1996 Jan;81 (1) :199-208. |[2]Orloff JJ, et al. Analysis of PTHRP binding and signal transduction mechanisms in benign and malignant squamous cells. Am J Physiol. 1992 May;262 (5 Pt 1) :E599-607. |[3]Guthalu Kondegowda N, et al. Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression. Diabetes. 2010 Dec;59 (12) :3131-8. |[4]Valín A, et al. C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca (2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Endocrinology. 2001 Jul;142 (7) :2752-9. |[5]Mozar A, et al. Parathyroid Hormone-Related Peptide (1-36) Enhances Beta Cell Regeneration and Increases Beta Cell Mass in a Mouse Model of Partial Pancreatectomy. PLoS One. 2016 Jul 8;11 (7) :e0158414. |[6]Portal-Núñez S, et al. Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett. 2010 Jul 16;584 (14) :3095-100.