(+) -SJ733
(+) -SJ733 is an anti-malaria agent which can also inhibit Na+-ATPase PfATP4.
Product Specifications
CAS Number
[1424799-20-1]
Product Name Alternative
SJ000557733
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335, H412
Target
Na+/K+ ATPase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/__addition__-SJ733.html
Purity
99.79
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@@H](C1=C2C=CC=C1)[C@@H](C3=CC=CN=C3)N(CC(F)(F)F)C2=O)NC4=CC=C(F)C(C#N)=C4
Molecular Formula
C24H16F4N4O2
Molecular Weight
468.40
Precautions
H302, H315, H319, H335, H412
References & Citations
[1]Jimenez-Diaz MB, et al. (+) -SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc Natl Acad Sci U S A. 2014 Dec 16;111 (50) :E5455-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Plasmodium
Available Sizes
Curated Selection
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