MS39
MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N- (3-Chloro-4-fluorophenyl) -7-methoxy-6- (3- (piperazin-1-yl) propoxy) quinazolin-4-amine (red part), E3 ligase ligand (S, R, S) -AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1].
Product Specifications
CAS Number
2675490-92-1
UNSPSC
12352005
Target
EGFR; PROTACs
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ms39.html
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C55H71ClFN9O7S
Molecular Weight
1056.72
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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