MS39

MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N- (3-Chloro-4-fluorophenyl) -7-methoxy-6- (3- (piperazin-1-yl) propoxy) quinazolin-4-amine (red part), E3 ligase ligand (S, R, S) -AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1].