MS39

MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N- (3-Chloro-4-fluorophenyl) -7-methoxy-6- (3- (piperazin-1-yl) propoxy) quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S, R, S) -AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S, R, S) -AHPC-CO-C9-acid (HY-139345) . MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells[1].

Product Specifications

CAS Number

[2675490-92-1]

UNSPSC

12352005

Target

EGFR; PROTACs

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ms39.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC(C(OCCCN1CCN(CC1)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O)=C5)=CC6=C5C(NC7=CC(Cl)=C(C=C7)F)=NC=N6

Molecular Formula

C55H71ClFN9O7S

Molecular Weight

1056.72

References & Citations

[1]Cheng M, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-Molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.