SSE15206
SSE15206 is a microtubule polymerization inhibitor (GI50 = 197 nM in HCT116 cells) that overcomes multidrug resistance. Causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation in cancer cells[1].
Product Specifications
CAS Number
[1370046-40-4]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319
Target
Apoptosis; Microtubule/Tubulin; Mitosis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SSE15206.html
Purity
99.88
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C(OC)=CC(C2N(C(N)=S)N=C(C3=CC=CC=C3)C2)=C1
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Precautions
H302, H312, H315, H319
References & Citations
[1]Manzoor S, et al. Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance. Sci Rep. 2018 Feb 19;8 (1) :3305.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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