SDZ 220-581

SDZ 220-581 is an orally active, potent, competitive NMDA receptor antagonist with pKi value of 7.7[1].

Product Specifications

CAS Number

[174575-17-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/SDZ-220-581.html

Purity

98.76

Solubility

DMSO : 8.57 mg/mL (ultrasonic; warming)

Smiles

ClC1=CC=CC=C1C2=CC(C[C@H](N)C(O)=O)=CC(CP(O)(O)=O)=C2

Molecular Formula

C16H17ClNO5P

Molecular Weight

369.74

Precautions

H315, H319, H335

References & Citations

[1]Urwyler S, Campbell E, Fricker G, Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35 (6) :655-69.|[2]Gilmour G, et al. In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39.