What is the catalog number for SYM 2081?

The catalog number for SYM 2081 is HY-101310.

What sizes are available for SYM 2081?

SYM 2081 is available in the following size(s): 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does SYM 2081 come in?

SYM 2081 is available in 5 different pack sizes.

Is SYM 2081 in stock?

SYM 2081 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures SYM 2081?

SYM 2081 is manufactured by QuantiMol.

What is the estimated delivery time for SYM 2081?

Estimated delivery time for SYM 2081 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for SYM 2081?

The safety data sheet for SYM 2081 is available here: http://file.medchemexpress.com/batch_PDF/HY-101310/SYM-2081-SDS-MedChemExpress.pdf.

SYM 2081

SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM) . SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression) . SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain[1][2][3][4].

Product Specifications

CAS Number

31137-74-3

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Bcl-2 Family; Caspase; EAAT; iGluR

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sym-2081.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](C[C@@H](C)C(O)=O)C(O)=O

Molecular Formula

C6H11NO4

Molecular Weight

161.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee JY, et al. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150 (4) :546-57.|[2]Vandenberg RJ, et al. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol Pharmacol. 1997 May;51 (5) :809-15.|[3]Turner MS, et al. SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia. Brain Res. 2003 May 30;973 (2) :252-64.|[4]Park J K, et al. SYM 2081 Exerts Neuroprotective Effect Modulating Anti-Apoptosis in the Hypoxic-Ischemic Brain Injury of Neonatal Rats[J]. Perinatology, 2019, 30 (3) : 117-125.