AG1557

AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194[1][2].

Product Specifications

CAS Number

[189290-58-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ag1557.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

COC1=CC2=NC=NC(NC3=CC=CC(I)=C3)=C2C=C1OC

Molecular Formula

C16H14IN3O2

Molecular Weight

407.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Akshada Joshi, et al. Identification of Potential Novel EGFR Inhibitors using a Combination of Pharmacophore and Docking Methods. International Journal of Pharmacy and Pharmaceutical Sciences, ISSN- 0975-1491 Vol 7, Issue 6, 2015|[2]Ellis AG, et al. High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma. J Chromatogr B Biomed Sci Appl. 2001 Apr 15;754 (1) :193-9.