HIV-1 protease-IN-13

HIV-1 protease-IN-13 (compound 18d) is a potent HIV-1 protease inhibitor with an IC50 value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) [1].

Product Specifications

UNSPSC

12352005

Target

HIV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-protease-in-13.html

Solubility

10 mM in DMSO

Smiles

OC1=C(O)C=C(CC(N[C@@H](CC2=CC=CC=C2)[C@H](O)CN(CC(C)C)S(C3=CC=C(OC)C=C3)(=O)=O)=O)C=C1

Molecular Formula

C29H36N2O7S

Molecular Weight

556.67

References & Citations

[1]Sihan Meng, et al. Rational design, synthesis and biological evaluation of novel HIV-1 protease inhibitors containing 2-phenylacetamide derivatives as P2 ligands with potent activity against DRV-Resistant HIV-1 variants. Bioorg Med Chem Lett. 2024 Feb 9:101:129651.