CPTH2 (hydrochloride)

CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) [1][2].

Product Specifications

CAS Number

[2108899-91-6]

UNSPSC

12352005

Target

Apoptosis; Histone Acetyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cpth2-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Cl

Molecular Formula

C14H15Cl2N3S

Molecular Weight

328.26

References & Citations

[1]Cocco E, et al. KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumoraggressiveness and target of KAT inhibitor CPTH2. Clin Epigenetics. 2018 Apr 4;10:44.|[2]Chimenti F, et al. A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4- (4'-chlorophenyl) thiazol-2-yl) hydrazone. J Med Chem. 2009 Jan 22;52 (2) :530-6.