MS-II-124

MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI) /acute respiratory distress syndrome (ARDS) [1].

Product Specifications

CAS Number

[3037332-85-4]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ms-ii-124.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 35 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1

Molecular Formula

C28H28ClFN2O4S

Molecular Weight

543.05

References & Citations

[1]Xu Y, et al. Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury[J]. Bioorganic Chemistry, 2024: 107562.