MS-II-124
MS-II-124 is an effective and selective NLRP3 inhibitor (IC50=0.12 μM) with anti-inflammatory and immunomodulatory activities, which can be used in the research of acute lung injury (ALI) /acute respiratory distress syndrome (ARDS) [1].
Product Specifications
CAS Number
3037332-85-4
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ms-ii-124.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(OCCC)C(CN(CCC2=CC=C(S(=O)(NCC#C)=O)C=C2)C(C3=CC=C(F)C=C3)=O)=C1
Molecular Formula
C28H28ClFN2O4S
Molecular Weight
543.05
References & Citations
[1]Xu Y, et al. Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury[J]. Bioorganic Chemistry, 2024: 107562.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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