EZM0414 (TFA)
Product Specifications
UNSPSC Description
EZM0414 TFA is a potent, selective and orally active inhibitor of SETD2 which is a human histone methyltransferase. EZM0414 TFA has anti-proliferative effects[1].
Target Antigen
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezm0414-tfa.html
Smiles
O=C(C(N1)=CC2=C1C(C)=CC=C2F)N[C@H]3C[C@@H](N4CCN(C(C)=O)CC4)CCC3.O=C(O)C(F)(F)F
Molecular Weight
514.51
References & Citations
[1]John Lampe, et al. Substituted indoles and methods of use thereof. WO2020037079A1.Cell Stem Cell. 2023 Apr 6;30(4):450-459.e9.|Nat Chem Biol. 2023 Mar 27.|Research Square Preprint. 2023 May 26.|Int J Biol Macromol. 2024 Oct 28:136767.|Sci Rep. 2024 Jun 3;14(1):12728.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-136328/EZM0414-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-136328/EZM0414-TFA-SDS-MedChemExpress.pdf
CAS Number
2411759-92-5
Available Sizes
Curated Selection
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