Menabitan (dihydrochloride)
Menabitan dihydrochloride (SP-204 dihydrochloride) is the dihydrochloride form of Menabitan. Menabitan dihydrochloride is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan dihydrochloride lowers the intraocular pressure in rabbit model[1].
Product Specifications
CAS Number
58019-50-4
Product Name Alternative
SP-204 (dihydrochloride)
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/menabitan-dihydrochloride.html
Smiles
O=C(C(CCN1CCCCC1C)C)OC2=CC(C(C(CCCCC)C)C)=CC3=C2C(CN(CC4)CC#C)=C4C(C)(C)O3.Cl.Cl
Molecular Formula
C37H58Cl2N2O3
Molecular Weight
649.77
References & Citations
[1]Anaebonam A O. Analytical, formulation development and stability testing of a lyophilized dosage form of menabitan hydrochloride, a new potent analgesic[M]. Massachusetts College of Pharmacy and Health Sciences, 1986.|[2]PITTENGER C, et al., Enhancement of the efficacy of serotonergic psychedelic drugs in the treatment or prevention of certain neuropsychiatric disorders through inhibition of type-9 phosphodiesterases. WO2024107445.|[3]Green K, et al., Acute dose response of intraocular pressure to topical and oral cannabinoids. Proc Soc Exp Biol Med. 1977 Feb;154 (2) :228-31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE9
Frequently Asked Questions
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