Polymyxin B
Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].
Product Specifications
CAS Number
1404-26-8
UNSPSC
12352211
Hazard Statement
H315-H319-H320
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/polymyxin-b.html
Purity
91.0
Solubility
H2O : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl)
Smiles
[PolymyxinB]
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.|[2]Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e02391-16. |[3]Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
ArXiv. 2025 Nov 7.|Biomed Pharmacother. 2023 Dec 31:169:115856.|bioRxiv. 2025 January 19.|Infect Genet Evol. 2025 Sep:133:105780.|Int J Antimicrob Agents. 2025 Jun 9:107551.|iScience. 2024 Sep 24;27 (10) :111027.|J Control Release. 2025 May 30:113907.|J Nanobiotechnology. 2025 Jul 1;23 (1) :465.|Prince of Songkla University. 2023 Dec.|ACS Nano. 2021 Mar 23;15 (3) :4173-4185.|Agronomy. 2024 Feb 8, 14 (2), 351.|bioRxiv. 2024 Dec 2:2024.11.27.625634.|bioRxiv. 2024 May 10.|Int J Pharm. 2022 Jan 25:612:121356.|J Antimicrob Chemother. 2020 Sep 1;75 (9) :2609-2615.|Mater Today Bio. 2025 Feb 18:31:101590.|Microbiol Spectr. 2022 Apr 27;10 (2) :e0273021.|Transl Psychiatry. 2022 Apr 7;12 (1) :146.
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