Polymyxin B

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].

Product Specifications

CAS Number

[1404-26-8]

UNSPSC

12352211

Hazard Statement

H315-H319-H320

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/polymyxin-b.html

Purity

91.0

Solubility

H2O : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

[PolymyxinB]

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.|[2]Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e02391-16. |[3]Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.