Tilorone (dihydrochloride)
Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS[1][2][3].Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV) [4].
Product Specifications
CAS Number
27591-69-1
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335, H351
Target
HIF/HIF Prolyl-Hydroxylase; Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tilorone-dihydrochloride.html
Purity
99.94
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C3=C1C=C(OCCN(CC)CC)C=C3)C=CC(OCCN(CC)CC)=C2.[H]Cl.[H]Cl
Molecular Formula
C25H36Cl2N2O3
Molecular Weight
483.47
Precautions
H302, H312, H315, H319, H332, H335, H351
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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