Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Tilorone (dihydrochloride)

Tilorone dihydrochloride is an orally active interferon (IFN) inducer with broad-spectrum antiviral activities. Tilorone dihydrochloride possesses robust anti-Severe fever with thrombocytopenia syndrome virus (SFTSV) activity in vitro and in vivo through stimulation of host innate immunity. Tilorone dihydrochloride can penetrate the blood-brain barrier to activate HIF in the CNS[1][2][3].Tilorone dihydrochloride exhibits an inhibitory activity with EC50 of 230 nM against Ebola virus (EBOV) [4].

Product Specifications

CAS Number

27591-69-1

UNSPSC

12352005

Hazard Statement

H302, H312, H315, H319, H332, H335, H351

Target

HIF/HIF Prolyl-Hydroxylase; Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tilorone-dihydrochloride.html

Purity

99.94

Solubility

DMSO : 12.5 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C3=C1C=C(OCCN(CC)CC)C=C3)C=CC(OCCN(CC)CC)=C2.[H]Cl.[H]Cl

Molecular Formula

C25H36Cl2N2O3

Molecular Weight

483.47

Precautions

H302, H312, H315, H319, H332, H335, H351

References & Citations

[1]Jingjing Yang, et al. Tilorone confers robust in vitro and in vivo antiviral effects against severe fever with thrombocytopenia syndrome virus. Virol Sin. 2022 Feb;37 (1) :145-148.|[2]Sean Ekins, et al. Tilorone, a Broad-Spectrum Antiviral for Emerging Viruses. Antimicrob Agents Chemother. 2020 Apr 21;64 (5) :e00440-20.|[3]Rajiv R Ratan, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Ann N Y Acad Sci. 2008 Dec:1147:383-94.|[4]Ekins S, et al., Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection. Antimicrob Agents Chemother. 2018 Jan 25;62 (2) :e01711-17.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

BNP (NPPB) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI7A8]
TA809080AM 100 µL

BNP (NPPB) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI7A8]

Sign In for Pricing
View Details
IRF3 Mouse Monoclonal Antibody [Clone ID: 3F10]
AM05643PU-N 100 µg

IRF3 Mouse Monoclonal Antibody [Clone ID: 3F10]

Sign In for Pricing
View Details
Frozen Tissue Sections, Prostate
CS622141 5x 5 µm

Frozen Tissue Sections, Prostate

Sign In for Pricing
View Details
Chromogranin A / CHGA (Neuroendocrine Marker) (CHGA/1815R), Biotin conjugate, 0.1mg/mL
BNCB1815-100 1x 100 µL

Chromogranin A / CHGA (Neuroendocrine Marker) (CHGA/1815R), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Nup53 (NUP35) (NM_001287585) Human Tagged ORF Clone
RG236576 10 µg

Nup53 (NUP35) (NM_001287585) Human Tagged ORF Clone

Sign In for Pricing
View Details
IRX6 Rabbit Polyclonal Antibody
TA368570 100 µL

IRX6 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details