Cholera toxin
Product Specifications
UNSPSC Description
Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER)[1]. Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein[2].
Target Antigen
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
96.0
Solubility
H2O : 10 mg/mL
Smiles
[Cholera toxin]
References & Citations
[1]Kellner A, et al. A binding motif for Hsp90 in the A chains of ADP-ribosylating toxins that move from the endoplasmic reticulum to the cytosol. Cell Microbiol. 2019;21(10):e13074.|[2]Tsai SC, et al. Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem. 1988;263(4):1768-1772.|[3]Wernick NL, et al. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010;2(3):310-325.
Shipping Conditions
Isolate blue ice and the product with bubble pack to avoid direct contact
Storage Conditions
Store at 4°C, do not freeze
Clinical Information
Launched
CAS Number
9012-63-9
Available Sizes
Curated Selection
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