SSRP1 rabbit pAb
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
Q08945
Swiss Prot
Q08945
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human SSRP1 AA range: 209-259
Target
SSRP1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus . Chromosome . Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. .
Gene ID (Human)
6749
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
USP1, CT (Ubiquitin Carboxyl-terminal Hydrolase 1, Ubiquitin Thioesterase 1, Ubiquitin-specific-processing Protease 1, Deubiquitinating Enzyme 1, hUBP) (MaxLight 650)
USP1, CT (Ubiquitin Carboxyl-terminal Hydrolase 1, Ubiquitin Thioesterase 1, Ubiquitin-specific-processing Protease 1, Deubiquitinating Enzyme 1, hUBP) (MaxLight 650)
Nerve Growth Factor Receptor, p75 (NGFR, NGF Receptor, CD271, Gp80 LNGFR, Low Affinity Nerve Growth Factor Receptor, Low Affinity Neurotrophin Receptor p75 NTR, p75 ICD, p75 Neurotrophin, p75 NTR, Tumor Necrosis Factor Receptor Superfamily Member 16, TNFR Superfamily Member 16, TNFRSF16) (APC) discontinued
