ITGA3 (heavy chain, Cleaved-Phe33) rabbit pAb

Integrin subunit alpha 3 (ITGA3) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015],

Product Specifications

Background

UniProt

P26006

Swiss Prot

P26006

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from human ITGA3 (heavy chain, Cleaved-Phe33)

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IF/ICC 1:50-200; ELISA 1:2000-20000; IHC-p 1:50-200

Molecular Weight

93 115kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

93 115kD

Fragment

IgG

Subcellular Location

Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor . Cell projection, invadopodium membrane ; Single-pass type I membrane protein . Cell projection, filopodium membrane ; Single-pass type I membrane protein . Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. .

Other Product Names

Integrin alpha-3 (CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]