PSI-6206-d1,13C,15N2
PSI-6206-d1,13C,15N2 is 15N and 13C labeled PSI-6206. PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Product Specifications
Product Name Alternative
RO 2433-d1,13C,15N2; GS-331007-d1,13C,15N2
UNSPSC
12352005
Target
HCV; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Others
Applications
COVID-19-anti-virus
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1[C@@H](O)[C@](F)(C)[C@@]([15N]2[13C]([15NH]C(C=C2)=O)=O)([2H])O1
Molecular Formula
C9 13CH12DF 15N2O5
Molecular Weight
264.20
References & Citations
[1]Wang P, et al. An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase. J Org Chem. 2009 Sep 4;74 (17) :6819-24.|[2]Clark JL, et al. Design, Synthesis, and Antiviral Activity of 2'-Deoxy-2'-fluoro-2'-C-methyl-cytidine, a Potent Inhibitor of Hepatitis C Virus Replication. J Med Chem. 2005 Aug 25;48 (17) :5504-8.|[3]Ma H, et al. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
 J Biol Chem. 2007 Oct 12;282 (41) :29|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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