Pyridostigmine (bromide)
Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that can be used in cardiovascular disease research[1][2][3][4][5].
Product Specifications
CAS Number
101-26-8
UNSPSC
12352005
Hazard Statement
H300+H310+H330, H317
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pyridostigmine-bromide.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 8.8 mg/mL (ultrasonic; warming)
Smiles
C[N+]1=CC=CC(OC(N(C)C)=O)=C1.[Br-]
Molecular Formula
C9H13BrN2O2
Molecular Weight
261.12
Precautions
H300+H310+H330, H317
References & Citations
[1]Gales BJ, et al. Pyridostigmine in the treatment of orthostatic intolerance. Ann Pharmacother. 2007 Feb;41 (2) :314-8. Epub 2007 Feb 6.|[2]Kanjwal K, et al. Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience. Pacing Clin Electrophysiol. 2011 Jun;34 (6) :750-5.|[3]Bernatova I, et al. Effect of chronic pyridostigmine bromide treatment on cardiovascular and behavioral parameters in mice[J]. Pharmacology Biochemistry and Behavior, 2003, 74 (4) : 901-907.|[4]de Cuba MB, et al. Effects of cholinergic stimulation with pyridostigmine bromide on chronic chagasic cardiomyopathic mice. Mediators Inflamm. 2014;2014:475946.|[5]Azzolin VF, et al. Effects of Pyridostigmine bromide on SH-SY5Y cells: An in vitro neuroblastoma neurotoxicity model. Mutat Res Genet Toxicol Environ Mutagen. 2017 Nov;823:1-10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AChE
Available Sizes
Frequently Asked Questions
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