Pyridostigmine (bromide)

Pyridostigmine bromide is an orally active cholinesterase (ChE) inhibitor that can be used in cardiovascular disease research[1][2][3][4][5].

Product Specifications

CAS Number

[101-26-8]

UNSPSC

12352005

Hazard Statement

H300+H310+H330, H317

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pyridostigmine-bromide.html

Concentration

10mM

Purity

99.07

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 8.8 mg/mL (ultrasonic; warming)

Smiles

C[N+]1=CC=CC(OC(N(C)C)=O)=C1.[Br-]

Molecular Formula

C9H13BrN2O2

Molecular Weight

261.12

Precautions

H300+H310+H330, H317

References & Citations

[1]Gales BJ, et al. Pyridostigmine in the treatment of orthostatic intolerance. Ann Pharmacother. 2007 Feb;41 (2) :314-8. Epub 2007 Feb 6.|[2]Kanjwal K, et al. Pyridostigmine in the treatment of postural orthostatic tachycardia: a single-center experience. Pacing Clin Electrophysiol. 2011 Jun;34 (6) :750-5.|[3]Bernatova I, et al. Effect of chronic pyridostigmine bromide treatment on cardiovascular and behavioral parameters in mice[J]. Pharmacology Biochemistry and Behavior, 2003, 74 (4) : 901-907.|[4]de Cuba MB, et al. Effects of cholinergic stimulation with pyridostigmine bromide on chronic chagasic cardiomyopathic mice. Mediators Inflamm. 2014;2014:475946.|[5]Azzolin VF, et al. Effects of Pyridostigmine bromide on SH-SY5Y cells: An in vitro neuroblastoma neurotoxicity model. Mutat Res Genet Toxicol Environ Mutagen. 2017 Nov;823:1-10.